Tenvir Em Tablets

Description

Comprehensive Patient & Clinician Guide to Tenvir-EM Tablet (Emtricitabine and Tenofovir Disoproxil Fumarate)

Tenvir-EM, manufactured by Cipla Pharmaceuticals Ltd., falls under a group of medicines called antiretrovirals, used effectively for treating HIV (human immunodeficiency virus), the primary cause of AIDS.

It helps control HIV infection, reducing the virus’s impact and allowing the immune system to function more effectively. Additionally, it helps to prevent HIV infection among the majority of people who are highly prone to risk. You can take this medicine alone or in combination with other HIV medicines.

Molecular Pharmacology & Mechanism of Action

Emtricitabine and tenofovir disoproxil fumarate are both classified as Reverse Transcriptase Inhibitors.

After being absorbed in the body, they undergo phosphorylation to become active metabolites, which are emtricitabine 5′-triphosphate and tenofovir

Synergistic Dual Mechanism

• Emtricitabine (NRTI): It competes with dCTP for incorporation into nascent HIV DNA.
• Tenofovir Disoproxil Fumarate (NtRTI): It competes with dATP for incorporation into the growing DNA chain of the virus.
• Chain Termination: These two molecules lack the 3′-OH group needed for the formation of phosphodiester bonds with the next nucleotide.
• The incorporation of these molecules terminates the elongation of the viral DNA chain, preventing integration of the virus into the genome of the human cell.

Approved Clinical Indications

Indications for the use of Tenvir-EM Tablets include adults and adolescents (>35 kg) in two clinical scenarios:

1. The treatment of HIV-1 infection.Used in combination with other antiretroviral medications as a dual NRTI base. It reduces viral load to undetectable levels and allows restoration of CD4+ T-cell immunity.

2. Prevention of sexually acquired HIV-1 infection (HIV-1 PrEP): Monotherapy (two drugs in one tablet) used for the prevention of acquisition of the virus in people without HIV-1 at risk of infection due to unprotected anal or vaginal intercourse.

3. Recommendations for Dosage and Administration: Strict adherence to the regimen prescribed by the infectious diseases specialist or primary healthcare physician.

Standard Dosage: Daily dose: one tablet orally once daily. With or Without Food: Tenvir-EM tablets may be taken with or without food. The intake of the drug together with meals helps to reduce mild nausea which occurs during the first several weeks of treatment.

Swallow Whole: Take the Tenvir-EM tablet whole together with water. Do not chew, break, or dissolve the tablet.

Essential PrEP Protocols & Timing

Missed Dose Instructions

• If you miss a dose by less than 12 hours, take it immediately and continue your normal schedule.

• If you are more than 12 hours late, skip the missed dose and resume your regular timing the next day.

• Never take a double dose to make up for a missed tablet.

PrEP Safety Rules: The 3 Non-Negotiable Requirements

• HIV-Negative Test Confirmed: An immediate HIV negative test result must be done before starting PrEP and must be repeated every three months while taking the drug. The use of Tenvir-EM in case of undetected HIV could lead to the mutation of HIV and development of resistance to emtricitabine and tenofovir.
• Protection from Other STIs Is Not Guaranteed: Tenvir-EM works to prevent the infection with HIV but does not protect from other Sexually Transmitted Infections like syphilis, gonorrhea, chlamydia, and HPV.
• Proper Dosing: Missing doses is associated with a significant decline in protective effect for those who take PrEP daily.

Key Benefits of Tenvir EM

Some of the key benefits of Tenvir-EM are the following:

• Tenvir-EM is a combination of Emtricitabine, Tenofovir, and Disoproxil Fumarate that suppresses HIV replication, slowing disease progression and helping maintain a stronger immune system.
• Tenvir-EM tablet prevents the spreading of HIV in the body, allowing the immune system to function more effectively.
• By lowering the viral load, Tenvir-EM reduces the chances of acquiring additional infections, ultimately improving overall health and quality of life.
• Taking the right dosage of Tenvir-EM medicine increases the effectiveness of the combination of medications and lowers the chances of getting infected with HIV. However, it does not prevent the transmission of HIV to others.
• By decreasing the viral load and increasing CD4 cell count, Tenvir-EM strengthens the immune response, helping the body better fight infections.

Dosage and Administration of Tenvir-EM

The dosage of Tenvir-EM varies based on individual medical conditions. It is essential to consult your doctor before taking this medication and strictly follow the prescribed instructions. Do not adjust your dosage without medical guidance.

The amount of medicine you take depends entirely on its strength. Additionally, the dosage required each day, the interval between doses, and the duration for which you need to take the medicine are all determined by the specific medical condition you are treating.

For Oral Dosage (Tablets)

For Treating HIV Infection

Each Tenvir-EM tablet contains 200 mg of emtricitabine and 300 mg of tenofovir. It is recommended for adults and children with a weight of 35 kilograms or more.
Children with a weight of 17kg to 35kg who are capable of swallowing a whole tablet should follow the doctor’s prescriptions:

• 28–35 kg: One tablet daily (167 mg emtricitabine, 250 mg tenofovir).
• 22–<28 kg: One tablet daily (133 mg emtricitabine, 200 mg tenofovir).
• 17–<22 kg: One tablet daily (100 mg emtricitabine, 150 mg tenofovir).
• <17 kg: Dosage as prescribed by a doctor.

For Preventing HIV Infection (Pre-exposure Prophylaxis)

• Adults & Children (35 kg): One tablet daily (200 mg emtricitabine, 300 mg tenofovir).
• Children (<35 kg): Dosage should be determined by a healthcare provider.

Strengths and Substitutes of Tenvir-EM

Tenvir-EM is a prescription medicine with a combination of Emtricitabine (200mg) and Tenofovir Disoproxil Fumarate (300mg), which is highly effective in managing the further spread of HIV-1 infections and preventing the transmission of this infection.

Taking the right dosage of this medicine reduces the chances of HIV occurrence among high-risk individuals.

The drug has minimal side effects, making it a popular choice among individuals. Additionally, it also improves the immune system.

Some of the common substitutes of Tenvir-EM medicine are as follows:

• Tenof EM Tablet
• Truvada 200 Mg
• Ricovir EM 200 mg
• Tavin EM Tablet
• Tentide EM Tablet

Side Effects of Tenvir-EM

Similar to other medicines, Tenvir-EM has several side effects. Some of the major and minor side effects of the Tenvir-EM tablet are the following:

• Fever or chills
• Pain in the chest
• Dizziness
• Diarrhoea
• Headache
• Nausea
• Abdominal pain
• Joint pain
• Rapid weight loss
• Rash
• Itching
• Passing gas
• Lactic Acidosis
  Considering these side effects, buy Tenvir-EM from a trusted pharmacy such as Indogenmed after consulting with your healthcare professional.

Safety and Precautions of Tenvir-EM

Here is a detailed list of safety precautions of Tenvir-EM you should follow before taking it:

• It is not safe to consume alcohol while taking a Tenvir-EM tablet. Make sure to consult your healthcare professional before using.
• Tenvir-EM is unsafe to use while breastfeeding. As a recent study reveals, the drug might cause toxic reactions to the baby.
• While taking Tenvir-EM, you may experience decreased alertness, visual impairment, and feelings of dizziness or drowsiness. If you encounter these symptoms, avoid driving.
• Take the Tenvir-EM tablet cautiously if you have existing kidney disease. Adjust the tablet dose as and when needed. Make sure to inform your doctor of all the pre-existing health conditions.
• Tenvir-EM is usually safe to use among patients with liver disease, and dosage adjustment is not needed among these patients.
• Make sure to consult with your healthcare professional before starting to take Tenvir-EM medicine.
• Follow the prescribed dosage and buy Tenvir-EM online, monitoring its side effects.

Disclaimer

This information is only for educational purposes. Always consult a doctor before you start or change dosages of medication as per your needs.

References

https://www.webmd.com/drugs/2/drug-22107-6330/tenofovir-disoproxil-fumarate-oral/tenofovir-oral/details
https://www.indianjournals.com/ijor.aspx?target=ijor:rjpt&volume=17&issue=5&article=047
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182838
https://pmc.ncbi.nlm.nih.gov/articles/PMC7163232/